The Bruins enter the matchup with Colorado riding a nine-game winning streak in the all-time series.
The guard averaged 25.7 points and 9.7 rebounds across UCLA's week of action.
Charisma Osborne averaged 25.7 points and notched a pair of career-high scoring performances in games against Oregon State, Washington and Washington State to win Freshman of the Week accolades.
The Bruins suffered just their fourth loss of the year.
The Bruins are winners of five of their last six games.
Charisma Osborne notched a career-high 32 points in the victory.